Structural Biology Facility Manager
Post Details
Job Title
Structural Biology Facility Manager
Post Number
1004561
Closing Date
7 Mar 2024
Grade
SC5
Starting Salary
£43,550 - £54,900
Hours per week
37
Project Title
N/A
Months Duration
Indefinite

Job Description

Main Purpose of the Job

An exciting opportunity has arisen for a Facility Manager to join the Structural Biology Platform at the John Innes Centre. The successful applicant will oversee the Platform, managing its personnel and resources, as well as being actively involved in research. They will become the focus for structural biology activity on site and will contribute to a wide variety of projects, with engagement ranging from simply offering advice through to becoming a major participant. The post holder will be expected to provide training to platform users in both formal and informal settings. They will keep abreast of new developments in the field, and adopt new practices where appropriate. The post holder will also manage the facility budget and ensure financial sustainability through facility usage recharges and funding applications.
 

Key Relationships

Initially, the post holder will work closely with the current Platform Manager and a technician. 

They will interact with a range of local research groups (mostly from JIC and the Sainsbury Laboratory) that require structural biology support, to include advice, assistance and training (both formal and informal). 

They will liaise with a variety of local support services, especially Research and Core Computing.

They will coordinate with the Bioimaging Platform to support cryo-EM research.

In time, they will take over as line manager to the Platform technician and assume responsibility for managing access to Diamond Light Source and the Electron BioImaging Centre. This will necessitate liaison with a variety of staff at these national facilities, as well as with the local users that require access. 



 

Main Activities & Responsibilities

Percentage
Structural biology research:
Solve and refine structures.
Analyse structures.
Validate and deposit structures and data in the appropriate repositories.
Prepare tables/figures/text for publications.
Provide advice/assistance with structural predictions. 
40
Act as coordinator for programme mode access to Diamond Light Source for X-ray crystallography and Small Angle X-ray Scattering data collections
Coordinate use of resultant beamtime with consortium members.
Lead data collection sessions involving JIC/TSL projects.
Triage, curate, backup and process data. 
Provide session feedback and prepare 6-monthly reports on beamtime usage and requests for future access.
15
General platform management tasks to include:
Oversee activity within platform. Identify and address deficiencies where possible. Review facilities and seek replacements for ageing equipment.
Line manage platform staff.
Keep abreast of new developments in the field – adopt new practices where appropriate.
Manage computational resources.
Attend the Technology Platforms Oversight Committee and Structural Biology Steering Group meetings; act as coordinator for the latter. 
Submit monthly recharges.
15
Prepare and deliver Structural Biology training to platform users through the following:
Formal training courses.
Informal tutorials/surgeries.
Hands-on computer training.
Preparation of help documents.
15
Act as coordinator for programme mode access to the Electron BioImaging Centre for cryo-EM data collections:
Coordinate use of resultant beamtime with consortium members.
(It is expected that data collection sessions will be led by Bioimaging Platform staff.)
Triage, curate, backup and process data. 
Provide session feedback and prepare 6-monthly reports on beamtime usage and requests for future access.
10
Other activities:
Act as co-signatory for other staff as appropriate.
Serve on studentship advisory panels as appropriate.
Participate in outreach activities as required.
Optionally: deliver structural biology lectures at UEA.
5
As agreed with line manager, any other duties commensurate with the nature of the role.

Person Profile

Education & Qualifications

Requirement
Importance
PhD in structural biology
Essential
First degree in Biological Science or relevant subject
Desirable

Specialist Knowledge & Skills

Requirement
Importance
In depth knowledge of protein crystallography
Essential
In depth knowledge of cryo-EM
Desirable
In depth knowledge of SAXS
Desirable

Relevant Experience

Requirement
Importance
Extensive postdoctoral research experience in structural biology
Essential
Experience of staff supervision
Desirable
Ability to manage budgets and secure funding
Desirable
Experience of managing a facility
Desirable

Interpersonal & Communication Skills

Requirement
Importance
Good communication skills, both written and verbal
Essential
Ability to deliver formal training courses
Essential
Self-motivated with the ability to work independently and as part of a team
Essential
Ability to initiate and nurture close relationships with users, group leaders and external contacts
Essential
Ability to interpret and convey complex information
Essential
Excellent organisational and time management skills
Essential

Additional Requirements

Requirement
Importance
Attention to detail
Essential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Ability to maintain confidentiality and security of information where appropriate
Essential
Willingness to undertake occasional travel (national and international) to perform experiments or attend workshops/conferences (Reasonable adjustments will be considered)
Essential
Promotes equality and values diversity
Essential
Willingness to work outside standard working hours when required
Essential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential

Who We Are

John Innes Centre

The John Innes Centre is an independent, international centre of excellence in plant and microbial genetics, carrying out fundamental and strategic research, to train scientists and making our findings available to society.

Our research makes use of a wide range of disciplines in the biological and chemical sciences including; cell biology, biochemistry, chemistry, genetics and molecular biology.

For more information about working at the John Innes Centre, please click here.

We pride ourselves on being a welcoming and inclusive working environment for all. We have a diverse and multicultural scientific community and thrive on our European and international links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on +44 (0)1603 450888 or nbi.recruitment@nbi.ac.uk.

We are proud to hold a prestigious Athena SWAN Gold award, recognising the impact of our work in promoting gender equality in science. We are also a proud member of the Stonewall Diversity Champion’s programme, a founding signatory of the Tecnician Commitment and, as a Disability Confident employer, guarantee to offer an interview to all disabled applicants who meet the essential criteria for the post.

The John Innes Centre is a registered charity (No. 223852), limited by guarantee (registered in England No. 511709).

Department

Biochemistry and Metabolism

Researchers within the Department of Biochemistry and Metabolism investigate the structure and function of biological macromolecules and fundamental aspects of plant and microbial metabolism. They aim to understand the mechanisms underpinning metabolic diversity and how to manipulate proteins, carbohydrates, small molecules and DNA, research which is facilitating advances of agricultural, environmental, medical and industrial importance.

Group Details

The Structural Biology Platform has established itself as crucial to the delivery of JIC science objectives, forming an integral component of forward research plans and contributing to the HP3 vision.

The Platform supports Protein Crystallography, Small Angle X-ray Scattering (SAXS) and cryo-EM, together with the provision of general structural biology advice and assistance with structural predictions.  

The Platform currently consists of a full-time manager and a part time technician. 

Living in Norfolk

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Structural Biology Facility Manager
Salary:            £43,550 - £54,900 per annum depending on qualifications and experience.
Contract:        Indefinite, full time.
Location:        John Innes Centre, Norwich, UK.
Closing date: 7 March 2024
Reference:     1004561

An exciting opportunity has arisen for a Facility Manager to join the Structural Biology Platform at the John Innes Centre.

About the John Innes Centre:

The John Innes Centre is an independent, international centre of excellence in plant and microbial sciences. We nurture a creative, curiosity-led approach to answering fundamental questions in bioscience, and translate that knowledge into societal benefits. Our strategic vision, Healthy Plants, Healthy People, Healthy Planet, sets out our ambitious long-term goals for the global impact of our science. 

Click here to find out more about working at the John Innes Centre.

About the Structural Biology Platform:

The Structural Biology Platform has established itself as crucial to the delivery of JIC science objectives, forming an integral component of forward research plans and contributing to the HP3 vision.

The facility underpins a wide variety of research programmes across the JIC site (extending to Norwich Research Park partner institutions), providing services and expertise for the determination of the three-dimensional structures of proteins of interest, principally using the techniques of protein X-ray crystallography (PX) and cryo-electron microscopy (cryo-EM). Secondary activities include Small Angle X-ray Scattering (SAXS), structure prediction, and the provision of general structural biology advice. 

JIC has regular programme mode access to Diamond Light Source for both PX and SAXS work and has recently secured the same for accessing the Electron BioImaging Centre for cryo-EM. Local cryo-EM data collection is enabled through the JIC Bioimaging facility, which is equipped with a Talos microscope fitted with a Falcon 4i detector.

The role:

The successful applicant will oversee the Structural Biology facility, managing its personnel and resources, as well as being actively involved in research. They will become the focus for structural biology activity on site and will contribute to a variety of projects, with engagement ranging from simply offering advice through to becoming a major participant. The post holder will be expected to provide training to platform users in both formal and informal settings. They will keep abreast of new developments in the field and adopt new practices where appropriate. The post holder will manage the facility budget and ensure financial sustainability through facility usage recharges and funding applications.

The ideal candidate:

You will have a PhD in Structural Biology. You will have in-depth knowledge of protein crystallography and demonstrable experience in structural biology.

The ideal candidate will have extensive postdoctoral research experience with the proven ability to independently determine macromolecular structures using protein crystallography; in depth knowledge of cryo-EM and SAXS would also be advantageous.

They must have excellent organisational skills, and experience of managing facilities, staff and budgets would be advantageous, as would the ability to secure funding to maintain and develop the facility.

The post holder must possess good oral and written communication skills, and the ability to act quickly to provide advice or troubleshoot any issues is important. The flexibility to work occasional unsociable hours and to undertake national and international travel are also required.

Additional information:

We are an equal opportunities employer, actively supporting inclusivity and diversity.  As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. We are proud to hold a prestigious Gold Athena SWAN award in recognition of our inclusive culture, commitment, and good practices towards advancing of gender equality. We offer an exciting, stimulating, diverse research environment and actively promote a family friendly workplace. The Institute is also a member of Stonewall’s Diversity Champions programme.

The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council.