Postdoctoral Researcher
Post Details
Job Title
Postdoctoral Researcher
Post Number
1003747
Closing Date
31 Aug 2019
Grade
SC6
Starting Salary
£31,625 - £38,575
Hours per week
37
Project Title
Quantitative analysis of DNA methylation maintenance within chromatin
Expected/Ideal Start Date
01 Jan 2020
Months Duration
23

Job Description

Main Purpose of the Job

Applications are invited for a Postdoctoral Researcher to join the laboratory of Dr Daniel Zilberman at the John Innes Centre (JIC). The successful candidate will work on a project supported by the European Research Council to achieve a quantitative understanding of how DNA methylation is epigenetically inherited. This project will involve applying bioinformatic approaches to explore DNA methylation-based epigenetics. This project will also entail a close collaboration with the Howard group at JIC to develop empirically supported mathematical models of DNA methylation-based epigenetic inheritance.

Key Relationships

Internal: Line manager, group members and, as necessary, other researchers, research support staff and students across the Institute.

External: Collaborators

Main Activities & Responsibilities

Percentage
Identify, plan, carry out and modify experiments to meet the objectives of the project
65
Prepare results, reports and manuscripts for publication in leading scientific journals and other relevant media
10
Disseminate research findings through presentations to various audiences at internal, national and international meetings
5
Collaborate with colleagues within the Institute in the development of original and world-class research, including contributing to research proposals and grant applications
5
Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements
5
Contribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellence
5
Continually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunities
5
As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees
Liaise with industry and other external stakeholders

Person Profile

Education & Qualifications

Requirement
Importance
PhD (full award or expected within 6 months) or equivalent in Biological Sciences or related discipline
Essential
BSc or equivalent in Biological Sciences or Computer Science
Essential

Specialist Knowledge & Skills

Requirement
Importance
Substantial knowledge of bioinformatics
Essential
In-depth understanding of epigenetics
Essential
Substantial knowledge of genomics
Essential

Relevant Experience

Requirement
Importance
Demonstrated ability to perform research and develop novel ideas
Essential
Proven record in scientific writing
Essential
Experience of oral research presentations
Essential
High quality publication record
Essential

Interpersonal & Communication Skills

Requirement
Importance
Excellent communication skills, both written and oral, including the ability to present complex information with clarity
Essential
Good interpersonal skills, with the ability to work as part of a team
Essential
Demonstrated ability to work independently, using initiative and applying problem solving skills
Essential
Excellent time management and organisational skills
Essential
Ability to collaborate with internal and external stakeholders
Essential
Ability to follow instructions/Standard Operating Procedures
Essential
Promotes and strives for continuous improvement
Essential

Additional Requirements

Requirement
Importance
Promotes equality and values diversity
Essential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential
Ability to maintain confidentiality and security of information where appropriate
Essential
Willingness to work outside standard working hours when required
Essential
Ability to undertake occasional travel (national and international) related to collaborations and/or seminars
Essential
Attention to detail
Essential

Who We Are

John Innes Centre

The John Innes Centre is an independent, international centre of excellence in plant science and microbiology, carrying out fundamental and strategic research, to train scientists and making our findings available to society.

Our research makes use of a wide range of disciplines in the biological and chemical sciences including; cell biology, biochemistry, chemistry, genetics and molecular biology.

For more information about working at the John Innes Centre, please click here.

We pride ourselves on being a welcoming and inclusive working environment for all. We have a diverse and multicultural scientific community and thrive on our European and international links, appointing staff from across the world. We expect this to continue post Brexit. However, any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on +44 (0)1603 450888 or nbi.recruitment@nbi.ac.uk.

We are proud to hold a prestigious Athena SWAN Gold award, recognising the impact of our work in promoting gender equality in science. We are also a proud member of the Stonewall Diversity Champion’s programme, a founding signatory of the Tecnician Commitment and, as a Disability Confident employer, guarantee to offer an interview to all disabled applicants who meet the essential criteria for the post.

The John Innes Centre is a registered charity (No. 223852), limited by guarantee (registered in England No. 511709).

Department

Cell & Developmental Biology

Development continues throughout the life of the plant. While many linear pathways affecting development have been discovered and are illustrated by elegant genetic studies, the challenge of the future will be for us to understand how these developmental pathways are integrated, both with themselves as well as with environmental signals, to enable a mature plant to grow from a seed.  Guided by evolutionary principles, the Department uses its knowledge of biological processes obtained in laboratory organisms such as Arabidopsis to understand processes in crop plants such as Brassicas and cereals.  To study this interaction of the plant genome with internal developmental networks and the environment, the Department uses a combination of genetic, cell biological, molecular and evolutionary strategies. The insights we are gaining provide both an increasingly detailed knowledge of the proteins involved in diverse regulatory mechanisms and a conceptual framework in which this knowledge can be related and eventually integrated into a molecular description of plant cell function.   The knowledge the department is creating is relevant to agriculture. Genes that control plant stature, form, over-wintering responses and growth are potentially useful for improving crop performance.

Group Details

The Zilberman laboratory (https://zilbermanlab.net/) studies the inheritance, function and evolution of DNA methylation, a key epigenetic mechanism that regulates gene expression in plants, animals and other eukaryotes. Proper inheritance of methylation patterns is essential for human health and plant development. Our group has been at the forefront of DNA methylation research for over ten years, and we regularly publish in the most prominent multidisciplinary journals, including Nature, Science, Cell, eLife and PNAS. Several previous members of the Zilberman group now hold independent faculty positions.

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Applications are invited for a Postdoctoral Researcher to join the Laboratory of Dr Daniel Zilberman at the John Innes Centre based in Norwich, UK.

The Zilberman Group:

The Zilberman laboratory (https://zilbermanlab.net/) studies the inheritance, function and evolution of DNA methylation, a key epigenetic mechanism that regulates gene expression in plants, animals and other eukaryotes. Proper inheritance of methylation patterns is essential for human health and plant development. Our group has been at the forefront of DNA methylation research for over ten years, and we regularly publish in the most prominent multidisciplinary journals, including Nature, Science, Cell, eLife and PNAS. Several previous members of the Zilberman group now hold independent faculty positions.

The role:

The successful candidate will work on a project supported by the European Research Council to achieve a quantitative understanding of how DNA methylation is epigenetically inherited. This project will involve applying bioinformatic approaches to explore DNA methylation-based epigenetics. This project will also entail a close collaboration with the Howard group at JIC to develop empirically supported mathematical models of DNA methylation-based epigenetic inheritance.

The successful candidate will identify, plan, carry out and modify experiments to meet the objectives of the project. They will also prepare results for publication and disseminate findings through presentations to various audiences at internal, national and international meetings.

The ideal candidate:

Applicants should possess a PhD (awarded or expected within 6 months) in Biological Sciences with a high-quality publication record and demonstrable scientific success in previous roles. Candidates should possess experience in bioinformatics, epigenetics and genomics, as well as excellent communication and interpersonal skills.

Additional information:

Salary on appointment will be within the range £31,625 to £38,575 per annum depending on qualifications and experience.  This is a fulltime contract for a period of 23 months.

We are an equal opportunities employer, actively supporting inclusivity and diversity.  As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. The John Innes Centre is also proud to hold a Gold Award from Athena SWAN and is a member of Stonewall’s Diversity Champions programme.